Mastering the innovative crafting systems in Resident Evil 9: Requiem requires a specialized approach, especially when playing as Grace Ashcraft. While Leon Kennedy follows a traditional system—automatically unlocking recipes as he acquires new weapons—Grace must actively conduct biological research to expand her arsenal.
Finding all Crafting Recipe locations is the only way to transform your harvested Infected Blood into the game's most potent munitions and survival tools. Securing every recipe is also a mandatory requirement for the "Master Craftsman" Trophy, which challenges you to craft every possible item in a single playthrough as Leon.
Early in the game, Grace unlocks recipes by finding Blood Specimens and analyzing them via the Laser Microscope minigame found in the Blood Lab. On the highest difficulty, an exclusive Insanity Blood Specimen is hidden within the Records Room. Analyzing it unlocks the recipe for the R.I.P. Knife and bulk Handgun Ammo.
Leon’s system is designed for speed and efficiency. He does not need to solve microscope puzzles; instead, his recipes are added to his inventory as soon as he acquires the relevant materials or firearms:
To use these recipes effectively, you must manage your raw resources and tool capacity:
Missing even one Blood Specimen can leave you without critical healing or firepower during the game's final descent. To prevent this, we have pinned every Crafting Recipe and Blood Specimen location on our RE9: Requiem Interactive Maps. Our map guides also provide the exact coordinates for the ID Wristbands needed to access locked labs. Use the links below to verify your progress.
| Name | Details | Map Location |
|---|---|---|
| Bottle of Acid | Found in the case on the cabinet in the Monitor Control Room. | ARK |
| Antique Coin Scrap | Found in the case on the cabinet. | ARK |
| Med Injector | Obtained by using the Blood Specimen (Converged) on the Analyzer in the Blood Lab. Note: On Casual and Standard difficulties, the Converged Blood Specimen is found in the Waiting Room Closet, while on Insanity difficulty, it is found in the Records Room. | Care Center |
| R.I.P. Knife (Insanity Difficulty Only) | Obtained by using the Blood Specimen (Polymerized) on the Analyzer in the Blood Lab. | Care Center |
| Handgun Ammo x30 (Insanity Difficulty Only) | Obtained by using the Blood Specimen (Polymerized) on the Analyzer in the Blood Lab. | Care Center |
| Makeshift Knife | Obtained automatically through story progression in the Care Center. | Care Center |
| Mixed Herb (G+G+G) | Obtained automatically through story progression in the Care Center. | Care Center |
| Scrap | Obtained automatically through story progression in the Care Center. | Care Center |
| Mixed Herb (G+G) | Obtained automatically through story progression in the Care Center. | Care Center |
| Hemolytic Injector | Unlocked by using the Blood Specimen (Denatured) on the Analyzer in the Blood Lab. | Care Center |
| Handgun Ammo x8 | Unlocked by using the Blood Specimen (Denatured) on the Analyzer in the Blood Lab. | Care Center |
| 12.7x55mm Ammo x2 | Obtained by using the Blood Specimen (Converged) on the Analyzer in the Blood Lab. Note: On Casual and Standard difficulties, the Converged Blood Specimen is found in the Waiting Room Closet, while on Insanity difficulty, it is found in the Records Room. | Care Center |
| Ink Ribbon | The Ink Ribbon Recipe is unlocked after you collect your first Ink Ribbon Tin. It is available only on Standard and Insanity difficulties. | Care Center |
| Steroids | Obtained by using the Blood Specimen (Reversible) on the Analyzer in the Blood Lab. | Care Center |
| Stabilizer | Obtained by using the Blood Specimen (Reversible) on the Analyzer in the Blood Lab. | Care Center |
| Shotgun Shells x3 | Automatically obtained after picking up the MSGB 500 weapon in the Attic. | Care Center |
| Hand Grenade | Automatically obtained after picking up your first Hand Grenade in the Attic. | Care Center |
| Stacked Hand Grenade | Automatically obtained after picking up your first Hand Grenade in the Attic. | Care Center |
| Molotov Cocktail | Found inside a case in the Bunkroom. | Care Center |
| Rifle Ammo x5 | Obtained automatically when you get the Classic 70 on the Roof. | Care Center |
| Handgun Ammo x10 | Obtained automatically after picking up the Gunpowder (Small) in Logistics Warehouse 1F locker. | East Raccoon City |
| Machine Gun Ammo x40 | Obtained automatically after grabbing the Gal weapon from the silver case. | East Raccoon City |
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